Inflation has emerged as a significant challenge for businesses globally, exerting pressure on supply chains, increasing costs, and threatening profitability. Economic uncertainty, driven by factors such as geopolitical instability, supply chain disruptions, and fluctuating commodity prices, has exacerbated inflationary trends, prompting organizations to rethink their supply chain strategies. Supply chain cost optimization has become crucial in this volatile environment, requiring a shift from traditional cost -cutting measures to more strategic approaches that focus on resilience, efficiency, and long -term sustainability. This research article explores the impact of rising inflation on supply chain operations and presents strategic approaches to cost optimization in the face of economic uncertainty. It highlights the importance of leveraging technology, data analytics, supplier collaboration, and risk management to navigate the challenges posed by inflation and ensure the continued success of supply chains. Through case studies and practical insights, this paper offers actionable recommendations for organizations seeking to maintain competitiveness and profitability in an inflationary environment.