In recent years, China’s environmental pollution is serious, manufacturing industry has become one of the main targets of government environmental regulation. This paper uses the SBM model to calculate efficiency value of 29 manufacturing industries from 2008 to 2017. The results show that the overall performance of environmental regulation in manufacturing industry is high (the average efficiency value is 0.7806), but it shows a declining trend. The efficiency of environmental regulation also varies widely. The government should consider focusing on the 11 industries with low SBM value in the next step to improve the performance of environmental regulation.