This article proposes a software fusion processing method for multi-sensor monitoring the Internet of Things based on the fractional differential filtering algorithm. The purpose is to solve the difference between the detection data caused by the difference in each production information sampling node’s equipment performance and working environment. The article applies the above algorithm to the remote detection data fusion processing experiment of the discrete manufacturing system of the Internet of Things. The research found that the algorithm realizes the remote high-precision measurement of the Internet of Things sensor information. The fractional integral operator has high fusion accuracy in remote detection data fusion processing.