This article uses the radial basis function artificial neural network and the MATLAB toolbox to study the vibration control of civil engineering structures. The article proposes a dynamic structure design method based on a generalized radial basis function neural network. Furthermore, the RBF neural network theory is used to optimize the structure-related controller parameters in geotechnical engineering. The research results show that RBF neural network can more accurately predict the vibration response of civil engineering. It can effectively solve the time lag problem in vibration control.