This paper extracts the basic elements of the integration of industry and education under the perspective of symbiosis theory and builds a symbiosis model in the communication and cooperation between symbiosis units according to the symbiosis units in the system of integration of industry and education. Influential factors were screened from different levels, and the DEMATEL method was used to determine the importance degree of system factors in combination with the explanatory structural model so as to construct the structural framework of influential factors. The weights of the influencing factors were finally confirmed through analysis, and empirical research was conducted on three colleges and universities, S1, S2, and S3. The overall performance level of S1 college and university integration is excellent, and the comprehensive judgment value of the college and university integration performance of this college and university is 85.342. The overall performance level of the two colleges and universities, S2 and S3, is good, and the comprehensive judgment value of the college and university integration performance of the two colleges and universities is 77.933 and 81.930, respectively. The evaluation study on the integration of industry and education can provide better recommendations for the integration path.