In this study, the integration of Building Information Modeling (BIM) and Virtual Reality (VR) technologies with performance analysis software facilitates the selection of optimal indoor space layouts for settlement buildings. This is achieved through the use of information modeling and visualization tools to assess various aspects such as sunlight exposure, lighting conditions, architectural parameters, and energy consumption across different building layouts. A virtual environment was created using BIM and VR, within which the collision detection algorithm was refined using a chime-playing test scenario to enhance the quality control of 3D models. At 5000 triangular slices, the detection algorithm optimized in this study demonstrated a real-time performance that is 19 milliseconds faster than that of the comparative algorithm. Furthermore, in scenarios involving micro-speed air exchange, an open window area of 30 square meters facilitated an air volume of 250,168, indicating both economic and practical benefits. The overall satisfaction with interior design and spatial arrangement achieved through BIM and VR integration consistently exceeds 80%, underscoring the synergistic potential and future-oriented trajectory of combining these technologies.