Teaching and learning are the main content of higher education, and in the traditional teaching mode of applied courses, there are problems such as the lack of scene support and the limitation of knowledge integration. This paper uses information technology to design a teaching content reconstruction strategy, integrates its application path in the “five-five model” of specialised integrated education under the concept of OBE, and then applies this strategy to the course content module in specialised integrated education. The study constructs an evaluation model for teaching effects using the PSO-RBF algorithm to assess the teaching effectiveness of this path. The RMSE based on PSO-RBF is 0.608, which allows for effective evaluation. Both the teaching effect evaluation model and the control experiment indicated that the teaching effect was better after the change to specialized and integrated education. It shows that it is effective to integrate the IT-based teaching content reconstruction strategy into the course content module in specialized creative and integrated education.