In the context of the new era, reforming “curriculum and political thinking” in the medical specialty of colleges and universities is a key path to realizing the fundamental task of cultivating moral integrity. The study adopts a blended teaching mode, combines online and offline resources, and focuses on analyzing the learning behavior of medical students. The correlation between learning behavior and performance was analyzed by DH-Kmeans cluster analysis algorithm and Pearson’s correlation coefficient. The experimental data came from the online learning behaviors of students in the 2022-2023 academic year of T Medical College, and a total of 2426 data were collected. The results showed that learning behaviors were highly correlated with grades, especially the number of tasks completed, course video progress, and the number of chapter studies. In addition, the comparative analysis of teaching experiments showed that students in the experimental class were better than the control class regarding ideological values, learning attitudes and grades. The conclusion shows that the blended teaching mode effectively improves medical students’ learning effect and the quality of ideological education.